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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MDM2 All Species: 8.79
Human Site: Y259 Identified Species: 21.48
UniProt: Q00987 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.33
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q00987 NP_001138811.1 491 55233 Y259 E S L D S E D Y S L S E E G Q
Chimpanzee Pan troglodytes XP_001155208 497 56032 Y265 E S L D S E D Y S L S E E G Q
Rhesus Macaque Macaca mulatta XP_001117336 491 55228 Y259 E S L D S E D Y S L S E E A Q
Dog Lupus familis XP_536098 519 58173 A285 V G I K V E A A D T E Q T S E
Cat Felis silvestris
Mouse Mus musculus P23804 489 54525 L259 L D S E D Y S L S D E G H E L
Rat Rattus norvegicus Q5XIN1 490 55202 A259 V G V K V E A A N C E Q P S E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511571 475 53775 D262 Q E L T D E D D E V Y Q V T L
Chicken Gallus gallus XP_417957 481 54617 V264 E T A D C E E V K E G D K K V
Frog Xenopus laevis P56273 473 53446 E260 E H G V S E E E E I N D E V Y
Zebra Danio Brachydanio rerio O42354 445 49931 D245 A Y S E N D V D S V P G E N E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 99.3 32.7 N.A. 81.4 32.5 N.A. 69.8 30.9 56.2 45.4 N.A. N.A. N.A. N.A. N.A.
Protein Similarity: 100 98.7 99.8 52.9 N.A. 87.7 52.5 N.A. 82.4 51.9 72.5 59.2 N.A. N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 93.3 6.6 N.A. 6.6 6.6 N.A. 20 20 26.6 13.3 N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 93.3 26.6 N.A. 13.3 33.3 N.A. 40 46.6 53.3 46.6 N.A. N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 10 0 0 0 20 20 0 0 0 0 0 10 0 % A
% Cys: 0 0 0 0 10 0 0 0 0 10 0 0 0 0 0 % C
% Asp: 0 10 0 40 20 10 40 20 10 10 0 20 0 0 0 % D
% Glu: 50 10 0 20 0 80 20 10 20 10 30 30 50 10 30 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 20 10 0 0 0 0 0 0 0 10 20 0 20 0 % G
% His: 0 10 0 0 0 0 0 0 0 0 0 0 10 0 0 % H
% Ile: 0 0 10 0 0 0 0 0 0 10 0 0 0 0 0 % I
% Lys: 0 0 0 20 0 0 0 0 10 0 0 0 10 10 0 % K
% Leu: 10 0 40 0 0 0 0 10 0 30 0 0 0 0 20 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 10 0 0 0 10 0 10 0 0 10 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 10 0 10 0 0 % P
% Gln: 10 0 0 0 0 0 0 0 0 0 0 30 0 0 30 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 30 20 0 40 0 10 0 50 0 30 0 0 20 0 % S
% Thr: 0 10 0 10 0 0 0 0 0 10 0 0 10 10 0 % T
% Val: 20 0 10 10 20 0 10 10 0 20 0 0 10 10 10 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 10 0 0 0 10 0 30 0 0 10 0 0 0 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _